Harnessing the power of stem cell science to revolutionize treatment of CNS diseases

The human brain contains different types of glial cells. These cells serve essential support and repair functions ensuring neuronal health. An ever increasing amount of  data prove that several diseases of the white matter and CNS are attributable to glial dysfunction.
Oscine Therapeutics will expand the possibilities for defeating degeneration and curing such diseases by replacing lost, damaged, or dysfunctional glia cells in patients with degenerative diseases and diseases of the white matter.

Glial cells in health and disease


Demyelinating disease such as secondary progressive multiple sclerosis (SPMS) and hereditary leukodystrophies including Pelizaeus-Merzbacher disease (PMD) emerge as attractive targets for myelinogenic oligodendrocyte replacement – being the only sole source of myelin in the adult CNS.


Astrocytes are required for neuronal survival and the loss of normal astrocyte function can be a primary contributor to neurodegeneration in Huntington’s Disease (HD), Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS).

Oscine’s pioneering cell platform generates bipotential astrocyte-oligodendrocyte glial progenitor cells

  • Based on decades of research by leading KOL Steven Alan Goldman
  • Capable of differentiating into two the key specialized cell types – astrocytes and oligodendrocytes
  • Capable of migration and proliferation
  • Can restore lost function through re-myelination
  • Can prevent neuronal loss
  • Can support neurons through energy support
  • Sensitive to contact-inhibition
  • Applicable to several cell types: iPSC, hESC

Broad indication space

Heraditary Leukodystrophies

  • Congenital dysmyelination
  • Pelizaeus-Merzbacher Disease

Metabolic leukodystrophies

  • Vanishing white matter disease
  • Adrenoleukodystrophy
  • Canavan’s Disease
  • Lysosomal storage diesases
  • Tay-Sachs, Sandhoff’s
  • Krabbe’s; NCL; MLD

Cerebral Palsy

  • Periventricular leaukomalacia
  • Spastics diplegias of prematurity

Age-related white matter loss

  • Subcortical dementia

Vascular Leukoencephalopathies

  • Subcortical stroke
  • Diabetic leukoenceohalopathy
  • Hypertensive leukoencephalopathy
  • Spinal cord injury

Autoimmune demyelination

  • Progressive multiple sclerosis
  • Transverse myelitis

Inflammatory demyelination

  • Radiation toxicity

Neurodegenerative diseases

  • Huntington Disease
  • ALS
  • Frontotemporal Dementia